• Clinically demonstrated formula designed to help to reverse the visible effects of glycation, a key contributor to skin aging
• Data to be presented via two posters at the Annual American Academy of Dermatology (AAD) Meeting in Orlando, FL

LOS ANGELES, March 3, 2025 /PRNewswire/ — skinbetter science® a leader in advanced skincare solutions, today announced the launch of BioRewind™, a skin health dietary supplement to improve visible skin quality by helping reduce Advanced Glycation Endproducts (AGEs).   

Glycation is a natural process where sugars bind to proteins, such as collagen and elastin, forming harmful substances called AGEs, which can stiffen these proteins and accelerate visible signs of aging. Without intervention, glycated collagen accumulates at an average annual rate of 3.7%.² BioRewind leverages proprietary CORExtract biotechnology comprises of rosemary extract and potent bioactive co-factors which help reverse the cumulative effects of early-stage glycation and skin aging at the source, resulting in healthier and younger looking skin.

“The launch of BioRewind marks a significant milestone for skinbetter science and medical grade skincare,” said Jonah Shacknai, CEO of skinbetter science®. “With BioRewind, we are introducing a new approach to counteract skin aging by addressing glycation, a lesser-known but extremely critical factor in the skin aging process. We are confident this innovation will redefine how we think about skin health.”

A double-blinded, randomized, placebo-controlled trial evaluated the safety and efficacy of BioRewind ™ in 104 patients over 12-weeks.

Key results showed that after 12-weeks, patients in the BioRewind treatment group experienced significant reductions compared to baseline:

• 30% reduction in rough skin texture
• 28% reduction in skin dullness
• 14% reduction in skin redness

Additionally, at 12 weeks a 17%  improvement in global skin quality was achieved in patients in the BioRewind treatment group compared to their baseline measurements.All of the results were statistically significant

Clinical and histological evidence will be available at the upcoming American Academy of Dermatology Meeting [Booth #1343] and will be forthcoming in the March issue of Journal of Clinical and Aesthetic Dermatology. Zoe Diana Draelos, MD, FAAD and Giuseppe Valacchi, PhD will present on “Reversing Glycation and Supporting Skin Quality with BioRewind Skin Health Dietary Supplement” at the L’Oréal R&I Theatre, Saturday March 8, 2:50 – 3:15pm.

BioRewind is designed to be incorporated into an individual’s daily routine.”The process and impact differs dramatically from typical topical treatments on the market because it works from the inside-out,” said Dr. Vivian Bucay, Bucay Center for Dermatology & Aesthetics. “This rosemary-based product is free of gluten, colorants, and dyes. My patients are excited to see results within just a few months by simply adding this into their existing skinbetter® routine.”

“This breakthrough formula is a game changer for skinbetter science and for our industry,” said Christian Bouchard, President Medical Aesthetic Skincare, North America, L’Oréal. “By targeting glycation, BioRewind enhances the skin’s appearance and is an invaluable tool for dermatologists aiming to offer comprehensive solutions to their patients.”

To learn more about BioRewind™ or find an authorized provider, visit www.skinbetter.com.

About skinbetter science ®

skinbetter science was formed in 2016 to establish a new biotech-based approach to skincare, built on three pillars: science, care and results. The team is committed to a technology pipeline of scientific innovation across multiple skincare categories, rigorous clinical substantiation of safety and efficacy of its products, as well as partnership with dermatologists, plastic surgeons, and other healthcare professionals in the aesthetic medical community in order to deliver best-in-class skincare solutions to their patients. skinbetter science is available exclusively through the leading dermatology, plastic surgery and medical aesthetics practices nationwide. To find an authorized skinbetter science physician near you, please visit www.skinbetter.com.

Media Contact:

EvolveMKD

skinbetter@evolvemkd.com

References

1. Draelos ZD, Gueniche A, Yatskayer M, Nelson DB. A Single-center, Double-blinded, Randomized, Placebo-controlled Trial Evaluated the Safety and Efficacy of a Dietary Supplement Containing Rosemary Extract on Visible Facial Skin Quality. J Clin Aesthet Dermatol. 2025;18(3): In press.
2. Guitto A, Pecorelli A, Draelos ZD, Gueniche A, Yatskayer M, Nelson DB. Reversing Oxinflammation Associated with Glycative Stress and Formation of Advanced Glycation Endproducts with a Dietary Supplement Containing Rosemary Extract. J Clin Aesthet Dermatol. 2025;18(3): In press.

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SOURCE skinbetter science